| Description | Ameltolide is an anticonvulsant agent. It has been shown to be effective at inhibiting seizures in animal models. |
| molecular weight | 240.3 |
| Molecular formula | C15H16N2O |
| CAS | 787-93-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (187.27 mM) |
| References | 1. Iman M, et al. Docking, Synthesis and Anticonvulsant Activity of N-substituted Isoindoline-1,3-dione. Iran J Pharm Res. 2017 Spring;16(2):586-595. 2. Iman M, Saadabadi A, Davood A. Docking studies of phthalimide pharmacophore as a sodium channel blocker. Iran J Basic Med Sci. 2013 Sep;16(9):1016-21. 3. Territo PR, et al. Nonlinear mixed effects pharmacokinetic/pharmacodynamic analysis of the anticonvulsant ameltolide (LY201116) in a canine seizure model. J Vet Pharmacol Ther. 2008 Dec;31(6):562-70. 4. Yogeeswari P, et al. Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3712-5. Epub 2007 Apr 13. |