| Description | Aluminum potassium sulfate (Potassium Aluminium Sulfate) is used in the study of severe acute respiratory syndrome and may be used in the prevention and treatment of cancer. |
| In vivo | Aluminum potassium sulfate（APS）以1g/kg /天的剂量持续给予小鼠60天，导致了学习和记忆能力缺陷。APS在体内浓度达到1g/kg 后，血液中铝（Al）水平仅在30天后上升。60天后，海马长短时程增强(STL)、乙酰胆碱(ACh)含量及胆碱乙酰转移酶(ChAT)活性分别下降了46.4%、8.5%和22.6%。当血液和大脑中铝含量增加后，90天时这些参数分别下降了50%、11.1%和27.8%。在乙基胆碱芥氮杂环氯化物（AF64A）处理的小鼠中，APS 1g/kg 仅增加了血液和大脑中的铝含量。 |
| Synonyms | Potassium Aluminium Sulfate, APS |
| molecular weight | 258.19 |
| Molecular formula | AlKO8S2 |
| CAS | 10043-67-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: < 1 mg/mL (insoluble） |
| References | 1. Lim SW. Aluminum potassium sulfate and tannic Acid injection for hemorrhoids. J Korean Soc Coloproctol. 2012 ; 28(2):73-77. 2. Wu YH, et al. Effects of aluminum potassium sulfate on learning, memory, and cholinergic system in mice. Zhongguo Yao Li Xue Bao. 1998 ; 19(6):509-512. 3. Sugawara C, et al. Decrease of serum triglyceride in normal rat fed with 2000 ppm aluminum diet for 67 days. II. Feeding young and adult rats a sucrose diet with addition of aluminum hydroxide and aluminum potassium sulfate. Fundam Appl Toxicol. 1988 ; 10(4):616-623. 4. Tsunoda A, et al. Serum aluminum levels in dialysis patients after sclerotherapy of internal hemorrhoids with aluminum potassium sulfate and tannic acid. Surg Today. 2014 ; 44(12):2314-2317. 5. Oneda S, et al. Chronic toxicity and tumorigenicity study of aluminum potassium sulfate in B6C3F1 mice. In Vivo. 1994 ; 8(3):271-278. 6. Yu D, et al. Toxicity detection of sodium nitrite, borax and aluminum potassium sulfate using electrochemical method. J Environ Sci (China). 2013 ; 25(4):785-790. |