| Description | α-Guanidinoglutaric Acid is found in cobalt-induced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric Acid-induced seizures are associated with abnormal serotonergic function and that they are initiated by a decrease in the 5-HT level. |
| In vivo | α-Guanidinoglutaric Acid 通过脑室内给药后，在大鼠中诱发了癫痫发作。在给药后4分钟，出现零星的低电压尖峰。尖峰电压在给药后6分钟增高。 |
| molecular weight | 189.17 |
| Molecular formula | C6H11N3O4 |
| CAS | 73477-53-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (290.74 mM) |
| References | 1. Burov S, et al. Incorporation of N-amidino-pyroglutamic acid into peptides using intramolecular cyclization of alpha-guanidinoglutaric acid. J Pept Sci. 2009 Nov;15(11):760-6. 2. Mori A, et al. alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats. J Neurochem. 1980 Sep;35(3):603-5. 3. Shiraga H, Hiramatsu M, Mori A. Convulsive activity of alpha-guanidinoglutaric acid and the possible involvement of 5-hydroxytryptamine in the alpha-guanidinoglutaric acid-induced seizure mechanism. J Neurochem. 1986 Dec;47(6):1832-6. |