| Description | α-Cyclodextrin (Alfadex) is a soluble fiber derived from corn and has beneficial effects on weight management in obese individuals with type 2 diabetes. |
| In vivo | α-Cyclodextrin在LDL受体敲除小鼠中优先降低饱和脂肪和反式脂肪的血液水平[2]。使用了两个独立的体内生物试验系统，分别是表达人类水通道蛋白的单细胞非洲爪蟾卵母细胞用于细胞水化研究，以及秀丽隐杆线虫用于测试处理动物的寿命。研究发现α-Cyclodextrin能够增强卵母细胞通过水通道的水分摄取。此外，α-Cyclodextrin还能促进秀丽隐杆线虫的长寿[3]。 |
| Synonyms | Alfadex, NSC269470, α-环糊精, NSC 269470, NSC-269470 |
| molecular weight | 972.84 |
| Molecular formula | C36H60O30 |
| CAS | 10016-20-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 40 mg/mL (41.12 mM) DMSO: 100 mg/mL (102.79 mM) |
| References | 1. Uesawa M, Muroi K, Ozawa K. Plasmapheresis-refractory transplantation-associated thrombotic microangiopathy successfully treated with pravastatin and limaprost alfadex. Ther Apher Dial. 2013 Aug;17(4):462-3. 2. Comerford KB, et al. The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans. Obesity (Silver Spring). 2011 Jun;19(6):1200-4. 3. Szente L, et al. Effects of alpha-cyclodextrin on water transport, cell hydration and longevity. Aging (Albany NY). 2021 Jan 19;13(2):1718-1728. 4. Inoue A, et al. Lichenoid Drug Eruption Caused by Limaprost Alfadex. Acta Derm Venereol. 2016 Nov 2;96(7):997-998. |