| Description | Alendronate sodium hydrate (MK 217) is a nitrogen-containing bisphosphonate, which is an effective inhibitor of bone resorption. It is utilized for the treatment and prevention of osteoporosis. |
| In vitro | 在小鼠中,一周一至两次0.1 mg/kg Alendronate预处理并联合使用10-50 mg/kg紫杉醇给药,可以阻断骨髓和软组织中PC-3 ML肿瘤的生长,并明显将生存时间提高到4-5周.在大鼠体内,Alendronate会增强吲哚美辛诱发的胃损伤,并延缓胃溃疡恢复.在兔子体内,Alendronate引起胃糜烂,同时增加吲哚美辛诱发的胃窦溃疡的发病率和面积. |
| In vivo | 阿仑膦酸钠,主要在破骨细胞中抑制胆固醇生物合成途径中的限速步骤。阿仑膦酸钠通过降低的香叶基香叶基二磷酸酯的水平,它可以干扰蛋白质异戊烯化,同时抑制类异戊二烯的生物合成途径。阿仑膦酸钠还以抑制0破骨细胞中的甾醇。 |
| Target activity | FPPS:460 nM. |
| Synonyms | G-704650, Alendronate, MK 217, Alendronate sodium trihydrate, 阿仑膦酸钠, G-704650 Adronat, Fosamax |
| molecular weight | 325.12 |
| Molecular formula | C4H12NO7P2·3H2O·Na |
| CAS | 121268-17-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Fisher JE, et al. Proc Natl Acad Sci U S A, 1999, 96(1), 133-138. 2. Bergstrom JD, et al. Arch Biochem Biophys, 2000, 373(1), 231-241. 3. Keller RK, et al. Biochem Biophys Res Commun, 1999, 266(2), 560-563. 4. Elliott SN, et al. Life Sci, 1998, 62(1), 77-91. 5. Stearns ME, et al. Invasion Metastasis, 1996, 16(3), 116-131. |