| Description | Alclometasone (7a-Chloro-16a-methyl prednisolone), a glucocorticoid, inhibits leukocytes from releasing pro-inflammatory mediators. It is effective in treating corticosteroid-responsive dermatoses such as atopic dermatitis, psoriasis, allergic dermatitis, and eczema [1]. |
| In vivo | The prodrug of alclometasone is alclometasone dipropionate[2]. Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) has no effects on hepatic drug metabolism in female rats or DS strain mice[2]. |
| Synonyms | 7a-Chloro-16a-methyl prednisolone |
| molecular weight | 408.92 |
| Molecular formula | C22H29ClO5 |
| CAS | 67452-97-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Alclometasone 2. Nishibe Y, et al. Species and sex differences in the inhibitory action of the corticosteroid alclometasone dipropionate on the hepatic drug-metabolizing system.Jpn J Pharmacol. 1989 Aug;50(4):435-43. |