Description | Alclofenac (W-7320) has a significant effect on the acute phase protein response and the degree of L-tryptophan binding to plasma protein and can be used in the treatment of patients with chronic rheumatism. |
Synonyms | W 7320, 烯氯苯乙酸, MY 101, BRN 2116510, W-7320, W7320 |
molecular weight | 226.66 |
Molecular formula | C11H11ClO3 |
CAS | 22131-79-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility | DMSO: 14 mg/mL (61.77 mM) |
References | 1. Knights KM, Winner LK, Elliot DJ, Bowalgaha K, Miners JO. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. Br J Clin Pharmacol. 2009 Sep;68(3):402-12. doi: 10.1111/j.1365-2125.2009.03469.x. PubMed PMID: 19740398; PubMed Central PMCID: PMC2766480. 2. Grimes DA, Hubacher D, Lopez LM, Schulz KF. Non-steroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD006034. Review. PubMed PMID: 17054271. 3. Selinsky BS, Gupta K, Sharkey CT, Loll PJ. Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry. 2001 May 1;40(17):5172-80. PubMed PMID: 11318639. 4. Fillet M, Bechet I, Piette V, Crommen J. Separation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes. Electrophoresis. 1999 Jul;20(9):1907-15. PubMed PMID: 10445335. |