| Description | AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1). |
| In vitro | AKT-IN-2 (Compound 8) also inhibits P70S6K, PKA, PKCβ2, RSK1, and pGSK3β (IC50s: 0.399, 0.084, 3.98, 0.568, and 0.092 μM). |
| Target activity | pGSK3β:92 nM, PKCβ2:3.98 μM, p70 S6K:399 nM, PKA:84 nM, Akt1:5 nM, RSK1:568 nM |
| molecular weight | 505.58 |
| Molecular formula | C25H34F3N7O |
| CAS | 1295514-91-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Parthasarathy S, et al. Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1887-1891. |