| Description | AKR1C3-IN-8 (Compound 5) is an effective and selective AKR1C3 inhibitor (IC50=0.069 μM). AKR1C3-IN-8 has antitumor activity. |
| In vitro | AKR1C3-IN-8 (Compound 5) shows antiproliferative activity with an IC 50 of 52.06 ± 0.99 μM against prostate cancer cell line 22rv1 [1]. AKR1C3-IN-8 (0-50 μM) inhibits PSA expression and testosterone production on 22RV1 cells [1]. |
| molecular weight | 400.43 |
| Molecular formula | C23H20N4O3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |