| Description | AKP-001 is a novel inhibitor of p38 MAPK. |
| molecular weight | 426.8 |
| Molecular formula | C21H13ClF2N4O2 |
| CAS | 897644-83-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Shirota K, Kaneko M, Sasaki M, Minato K, Fujikata A, Ohta S, Hisaka A, Suzuki H. Analysis of the disposition of a novel p38 MAPK inhibitor, AKP-001, and its metabolites in rats with a simple physiologically based pharmacokinetic model. Drug Metab Dispos. 2015 Feb;43(2):217-26. doi: 10.1124/dmd.114.060046. Epub 2014 Nov 24. PubMed PMID: 25422274. 2. Hasumi K, Sato S, Saito T, Kato JY, Shirota K, Sato J, Suzuki H, Ohta S. Design and synthesis of 5-[(2-chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isox azole (AKP-001), a novel inhibitor of p38 MAP kinase with reduced side effects based on the antedrug concept. Bioorg Med Chem. 2014 Aug 1;22(15):4162-76. doi: 10.1016/j.bmc.2014.05.045. Epub 2014 Jun 3. PubMed PMID: 24938496. |