| Description | AK 275 is a calpain inhibitor that prevents degradation of cytoskeletal and myelin proteins in spinal cord in vitro. |
| Synonyms | AK275, AK-275 |
| molecular weight | 377.48 |
| Molecular formula | C20H31N3O4 |
| CAS | 158798-83-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. James T, Matzelle D, Bartus R, Hogan EL, Banik NL. New inhibitors of calpain prevent degradation of cytoskeletal and myelin proteins in spinal cord in vitro. J Neurosci Res. 1998 Jan 15;51(2):218-22. PubMed PMID: 9469575. 2. Zalewska T. Calpain as proposed target for neuroprotective treatment of brain ischemia. Folia Neuropathol. 1996;34(3):121-7. Review. PubMed PMID: 8946783. 3. Bartus RT, Baker KL, Heiser AD, Sawyer SD, Dean RL, Elliott PJ, Straub JA. Postischemic administration of AK275, a calpain inhibitor, provides substantial protection against focal ischemic brain damage. J Cereb Blood Flow Metab. 1994 Jul;14(4):537-44. PubMed PMID: 8014200. |