| Description | AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 μM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells. |
| In vitro | AK-1 induces the formation of α-synuclein aggregates in H4 neuroglioma cells expressing α-synuclein and synphilin-1.AK-1 (5 μM) decreases total cholesterol levels in Neuro2a and primary rat striatal neurons, as well as in hippocampal slice cultures[1]. |
| Target activity | SIRT2:12.5 μM |
| molecular weight | 403.45 |
| Molecular formula | C19H21N3O5S |
| CAS | 330461-64-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 40 mg/mL (99.14 mM) |
| References | 1. Taylor D M , Balabadra U , Xiang Z , et al. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase[J]. ACS Chemical Biology, 2011, 6(6):540-546. 2. Outeiro T F , Kontopoulos E , Altmann S M , et al. Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease[J]. Science, 317. |