| Description | AI-10-47 (1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47) is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM). |
| In vitro | AI-10-47显著抑制了ME-1、TUR、M0-91、THP-1以及U937细胞的生长；而以10μM浓度，AI-10-47对CBFβ-RUNX的结合有弱抑制作用。 |
| Target activity | CBFβ-RUNX binding:3.2 μM |
| Synonyms | 1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47 |
| molecular weight | 279.22 |
| Molecular formula | C13H8F3N3O |
| CAS | 1256094-31-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (358.14 mM), Sonication is recommended. |
| References | 1. Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131. |