| Description | AHR-10037 is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties as well as a high therapeutic index and low gastric toxicity. AHR-10037 was comparable to indomethacin in suppressing acute (Evans blue-carrageenan pleural effusion) and chronic (adjuvant-induced arthritis) inflammation. Studies have shown that it is converted in vivo to a prodrug of cyclooxygenase inhibitors. |
| molecular weight | 288.73 |
| Molecular formula | C15H13ClN2O2 |
| CAS | 78281-73-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Sancilio LF, Nolan JC, Wagner LE, Gathright CE, Droppleman DD, Alphin RS, Walsh DA, Welstead WJ Jr. AHR-10037, a non-steroidal anti-inflammatory compound of low gastric toxicity. Agents Actions. 1990 Aug;31(1-2):117-26. PubMed PMID: 2285017. 2. Walsh DA, Moran HW, Shamblee DA, Welstead WJ Jr, Nolan JC, Sancilio LF, Graff G. Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid. J Med Chem. 1990 Aug;33(8):2296-304. PubMed PMID: 2115589. |