| Description | AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). AH 6809 has a Ki of 350 nM for mouse EP2 receptor. |
| Target activity | EP3:1597 nM (Ki)(human), DP:1415 nM (Ki)(human), EP2:1150 nM (Ki)(human), EP2:350 nM (Ki)(mouse), EP1:1217 nM (Ki)(human) |
| molecular weight | 298.29 |
| Molecular formula | C17H14O5 |
| CAS | 33458-93-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (83.81 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) |
| References | 1. http://www.millipore.com/publications.nsf/a73664f9f981af8c852569b9005b4eee/cae2c825891fb78e85257b19005fa865/$FILE/HTS099C%20ep1%20datasheet%20121212.pdf 2. Keery RJ, et al. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br J Pharmacol. 1988 Jul;94(3):745-54. 3. Capehart AA, et al. Effects of a putative prostaglandin E2 antagonist, AH6809, on chondrogenesis in serum-free cultures of chick limb mesenchyme. J Cell Physiol. 1991 Jun;147(3):403-11. 4. Piazuelo E, et al. Characterization of the prostaglandin E2 pathway in a rat model of esophageal adenocarcinoma. Curr Cancer Drug Targets. 2012 Feb;12(2):132-43. 5. Rutkai I, et al. Activation of prostaglandin E2 EP1 receptor increases arteriolar tone and blood pressure in mice with type 2 diabetes. Cardiovasc Res. 2009 Jul 1;83(1):148-54. |