| Description | AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death. |
| In vitro | AGX51抑制Id1-E47相互作用。在小鼠中，AGX51具有良好的耐受性，并且通过抑制视网膜新生血管形成，在AMD和ROP模型中模拟了Id表达的遗传缺失。AGX51可能在多种疾病的管理中具有潜在应用价值[1]。 |
| molecular weight | 431.52 |
| Molecular formula | C27H29NO4 |
| CAS | 330834-54-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: 95 mg/mL (220.15 mM), Sonication is recommended. DMSO: 95 mg/mL (220.15 mM), Sonication is recommended. |
| References | 1. Wojnarowicz PM, et al. A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep. 2019 Oct 1;29(1):62-75.e7. |