| Description | Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors. |
| Synonyms | Aganodin |
| molecular weight | 245.11 |
| Molecular formula | C9H10Cl2N4 |
| CAS | 86696-87-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Molderings GJ, Bönisch H, Hammermann R, Göthert M, Brüss M. Noradrenaline release-inhibiting receptors on PC12 cells devoid of alpha(2(-)) and CB(1) receptors: similarities to presynaptic imidazoline and edg receptors. Neurochem Int. 2002 Feb;40(2):157-67. PubMed PMID: 11738482. 2. Sánchez-Blázquez P, Boronat MA, Olmos G, García-Sevilla JA, Garzón J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000 May;130(1):146-52. PubMed PMID: 10781010; PubMed Central PMCID: PMC1572044. 3. Molderings GJ, Likungu J, Göthert M. Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship. Naunyn Schmiedebergs Arch Pharmacol. 1999 Aug;360(2):157-64. PubMed PMID: 10494885. 4. Göthert M, Brüss M, Bönisch H, Molderings GJ. Presynaptic imidazoline receptors. New developments in characterization and classification. Ann N Y Acad Sci. 1999 Jun 21;881:171-84. Review. PubMed PMID: 10415912. |