| Description | ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 with an IC50 of 1.1 µM and can be used in studies about cartilage destruction in arthritis. |
| molecular weight | 449.92 |
| Molecular formula | C16H11ClF3N3OS3 |
| CAS | 929634-33-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 74.7 mg/mL (166 mM), Sonication is recommended. |
| References | 1. Gilbert AM, et al. 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1189-92. 2. Wylie JD, et al. Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines. J Orthop Res. 2012 Feb;30(2):226-33. |