ACTH 11-24 acetate(4237-93-8 free base) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	ACTH 11-24 acetate(4237-93-8 free base) (Adrenocorticotropic Hormone (11-24) acetate) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.
In vitro	ACTH (11-24) 作为肾上腺皮质激素受体的拮抗剂[1]。在新鲜分散或培养的牛肾上腺皮质细胞中，ACTH (11-24) 能次最大限度地诱导皮质醇分泌。ACTH (11-24) 引起的皮质醇最大释放量可被forskolin增强，但被钙通道阻断剂所抑制[2]。
In vivo	ACTH (11-24) 在大鼠中阻断电针（EA）的抗水肿作用，但不影响EA的抗高敏反应[1]。
Synonyms	Adrenocorticotropic Hormone (11-24) acetate
molecular weight	1712.12
Molecular formula	C79H138N24O18
CAS	79190-56-0
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: Insoluble H2O: 10 mM
References	1. Li ZG, et al. Adrenocorticotropin(1-10) and -(11-24) promote adrenal steroidogenesis by different mechanisms. Endocrinology. 1989 Aug;125(2):592-6.

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