| Description | ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM). |
| In vitro | ACTH (1-17) acetate在大鼠腺垂体培养中，即使使用微摩尔浓度的肽，也只会引起生长激素分泌轻微且不显著的增加[1]。ACTH (1-17) acetate对alpha-MSH显示出了亲和力，Ki值为0.13±0.005 nM[1]。 |
| In vivo | 夜行性动物开始活动时，若在每日暗期开始后2小时给予ACTH (1-17) acetate，便观察到DNA标记的抑制现象。在该昼夜节律阶段给药，特别是较大剂量与DNA标记的24小时持续抑制相关联。若相同剂量提前4小时注射，抑制效应显著缩短[2]。 |
| Target activity | MC1R (human):0.21 nM(Ki) |
| molecular weight | 2153.47 |
| Molecular formula | C97H149N29O25S |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Ceda GP, et al. The effects of ACTH (1-17) on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3. 2. Walker WV, et al. Effect of an adrenocorticotropin analogue, ACTH (1-17), on DNA synthesis in murine metaphyseal bone. Biochem Pharmacol. 1985 Apr 15;34(8):1191-6. 3. Tsatmali M et al. ACTH1-17 is a more potent agonist at the human MC1 receptor than alpha-MSH. Cell Mol Biol (Noisy-le-grand). 1999 Nov;45(7):1029-34. |