| Description | Acreozast, a histamine release inhibitor, is used potentially for the treatment of asthma and atopic dermatitis. |
| Synonyms | TYB 2285, TYB-2285, TYB2285 |
| molecular weight | 367.74 |
| Molecular formula | C15H14ClN3O6 |
| CAS | 123548-56-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Tohda Y, Muraki M, Kubo H, Nakajima S, Fukuoka M, Watanabe A. Effect of TYB-2285 on early and late bronchial responses and airway hyperreactivity in actively sensitized guinea pigs. Gen Pharmacol. 1998 Aug;31(2):323-8. PubMed PMID: 9688481. 2. Abraham WM, Ahmed A, Cortes A, Sielczak M, Wantanabe A. Effect of TYB-2285 on antigen-induced airway responses in sheep. Pulm Pharmacol. 1996 Feb;9(1):49-58. PubMed PMID: 8843510. 3. Watanabe A, Tominaga T, Shutoh H, Hayashi H, Tsuji J. Effect of TYB-2285 on peritoneal anaphylaxis in passively sensitized rats. Gen Pharmacol. 1998 Aug;31(2):313-7. PubMed PMID: 9688479. 4. Tominaga T, Watanbe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract. Gen Pharmacol. 1997 Mar;28(3):411-4. PubMed PMID: 9068982. |