| Description | Acid-PEG4-C2-Boc is a linker compound based on polyethylene glycol (PEG) and alkyl/ether. It is utilized in the synthesis of PROteolysis TArgeting Chimeras (PROTACs) for the purpose of inhibiting the mechanistic Target of Rapamycin (mTOR)[1]. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| molecular weight | 350.4 |
| Molecular formula | C16H30O8 |
| CAS | 1835759-85-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Jennifer PITZEN , et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1. |