Acetyl Angiotensinogen (1-14), porcine Acetate Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Acetyl Angiotensinogen (1-14), porcine Acetate is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor.
In vitro	该化学化合物的活性描述如下：通过70%的丙酮从血液中提取肾素-血管紧张素系统，并表现出短暂的升压效果。肾素以酶的方式作用于一种血浆蛋白，产生了新的物质。
In vivo	由Angiotensinogen基因编码的蛋白质称为前血管紧张素原或血管紧张素原。前血管紧张素原在肝脏中表达，并在血压降低时被酶肾素裂解。裂解产物血管紧张素I随后被血管紧张素转换酶(ACE)裂解，生成生理活性酶血管紧张素II。血管紧张素II参与维持血压，并与基本高血压和子痫前期的病理发生有关[2]。
Synonyms	Acetyl Angiotensinogen (1-14), porcine Acetate（66641-26-7 Free base）
molecular weight	1861.1
Molecular formula	C89H129N21O23
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 162 mg/mL (89.95 mM)
References	1. Pierre, Corvol. [History of the discovery of the renin-angiotensin system].[J]. La Revue Du Praticien, 2018. 2. Skurk T , Lee Y M , Hauner H . Angiotensin II and Its Metabolites Stimulate PAI-1 Protein Release From Human Adipocytes in Primary Culture[J]. Hypertension, 2001, 37(5):1336-40.

PeptideDB