| Description | Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and altitude sickness. |
| In vitro | Acetazolamide sodium （0-160μM）+ MS-275 （0.75 μM）组合剂量依赖性抑制了 NB 细胞系 SH-SY5Y 的生长，诱导了细胞周期停滞和凋亡，并降低了迁移能力[1]。 |
| In vivo | 在临床前异种移植模型中，Acetazolamide sodium（40 mg/kg）、MS-275 （20 mg/kg） 和 Acetazolamide sodium + MS-275 （40 + 20 mg/kg） 处理 14 天，这种组合显著抑制了体内肿瘤的生长，HIF-1α 和 CAIX 的表达显著降低，SH-SY5Y 的 NB 异种移植物细胞凋亡显著增加[1]。 |
| Synonyms | OT-302 sodium |
| molecular weight | 244.23 |
| Molecular formula | C4H5N4NaO3S2 |
| CAS | 1424-27-7 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 80 mg/mL (4.08 mM), Sonication is recommended. DMSO: 80 mg/mL (4.08 mM), Sonication is recommended. |
| References | 1. Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156. |