| Description | Ac9-25 acetate is an annexin AI peptide and activates the neutrophil reduced nicotinamide adenine dinucleotide phosphate oxidase through FPR but not through FPRL1. |
| In vitro | 在20 μM的浓度下，N-terminal annexin I peptides Ac9-25 acetate 明显干扰中性粒细胞的跨内皮迁移。来源于其他annexins N-terminal domains的肽段未显示出抑制效果。滴定实验表明，使用Ac9-25 acetate的annexin I peptide在约5 μM时观察到中性粒细胞迁移被50%抑制[1]。 |
| Synonyms | Ac9-25 acetate(284040-76-2 free base) |
| molecular weight | 2243.38 |
| Molecular formula | C101H147N23O35 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Karlsson J, et al. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol. 2005;78(3):762-771. 2. Walther A, et al. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5(5):831-840. |