| Description | AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9. |
| In vitro | AC-55649 is a potent and selective activator of RARβ2 transcriptional activity[2]. AC-55649 is a potent, highly isoform-selective agonist at the human RARβ2 receptor, with a pEC50 of 6.9[1]. |
| Target activity | RARβ2:6.9 （pEC50） |
| molecular weight | 310.43 |
| Molecular formula | C21H26O2 |
| CAS | 59662-49-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (289.9 mM), Sonication is recommended. |
| References | 1. Lund BW, et al. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9. 2. Piu F, et al. Identification of novel subtype selective RAR agonists. Biochem Pharmacol. 2005 Dec 19;71(1-2):156-62. |