| Description | ABT-418 hydrochloride is a selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. It activates cholinergic channel and can be used for the research of Alzheimer's disease. |
| In vivo | Animal Model: Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model;Dosage: 0.6 mg/kg;Administration: i.p.; once daily; for two weeks [2] |
| molecular weight | 202.68 |
| Molecular formula | C9H15ClN2O |
| CAS | 147388-83-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. 2. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5. |