| Description | Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor. It has anti-HIV and immunomodulatory activity, induces arterial thrombosis in a mouse model, and can be used to study HIV infection. |
| In vivo | 在6至8周龄的雄性和雌性SCID小鼠中，这些小鼠植入了银屑病组织，Abacavir hydroxyacetate（10和20 mg/kg；口服灌胃；10-20 mg/kg一次）能够减少PRINS和IL-20的浓度，并减少皮肤病变区域，显示出比甲氨蝶呤更好的效果来控制银屑病[1]。 |
| Synonyms | Abacavirhydroxyacetate |
| molecular weight | 344.37 |
| Molecular formula | C16H20N6O3 |
| CAS | 1446418-48-9 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (232.31 mM), Sonication is recommended. |
| References | 1. Guda A, et al. Investigational drugs in phase II clinical trials for moderate to severe plaque psoriasis - potential new treatments on the horizon. Expert Opin Investig Drugs. 2018 Nov;27(11):931-939. |