| Description | AA92593 has been used as a selective inhibitor of melanopsin. |
| In vitro | The involvement of melanopsin in the regulation of melatonin was also determined by using a specific inhibitor AA92593 and by inhibiting melanopsin-induced phospholipase C activation. Under this situation neither AANAT nor melatonin levels changed under light conditions (n = 4, ***p < 0.001). The discovery of melanopsin in the lens opens the possibility of regulating melatonin synthesis with the corresponding implication as an antioxidant substance[1]. |
| molecular weight | 269.36 |
| Molecular formula | C13H19NO3S |
| CAS | 457961-34-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 22.5 mg/mL (83.53 mM) |
| References | 1. Alkozi H A , Wang X , Jesus P D L M , et al. Presence of melanopsin in human crystalline lens epithelial cells and its role in melatonin synthesis[J]. Experimental Eye Research, 2016:168. 2. Hehr, Carrie, L, et al. Melanopsin photoreception in the eye regulates light-induced skin colour changes through the production of -MSH in the pituitary gland[J]. Pigment cell & melanoma research, 2015. |