| Description | AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins that regulate ATF6 activity. |
| Synonyms | ATF6-activator-147 |
| molecular weight | 255.31 |
| Molecular formula | C16H17NO2 |
| CAS | 393121-74-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 25 mg/mL (97.92 mM) |
| References | 1. Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1. |