PeptideDB

A68930

CAS No.: 130465-45-1

A 68930 is a dopamine D-1 receptor antagonist. A 68930 inhibits NLRP3 inflammasome activity.
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Description A 68930 is a dopamine D-1 receptor antagonist. A 68930 inhibits NLRP3 inflammasome activity.
Synonyms A 68930, A70108, A-68930, A 70108, A-70108
molecular weight 271.31
Molecular formula C16H17NO3
CAS 130465-45-1
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Jiang W, Huang Y, He F, Liu J, Li M, Sun T, Ren W, Hou J, Zhu L. Dopamine D1 Receptor Agonist A-68930 Inhibits NLRP3 Inflammasome Activation, Controls Inflammation, and Alleviates Histopathology in a Rat Model of Spinal Cord Injury. Spine (Phila Pa 1976). 2016 Mar;41(6):E330-4. doi: 10.1097/BRS.0000000000001287. PubMed PMID: 26966979. 2. Jiang W, Li M, He F, Bian Z, Liu J, He Q, Wang X, Sun T, Zhu L. Dopamine D1 receptor agonist A-68930 inhibits NLRP3 inflammasome activation and protects rats from spinal cord injury-induced acute lung injury. Spinal Cord. 2016 Nov;54(11):951-956. doi: 10.1038/sc.2016.52. Epub 2016 Apr 12. PubMed PMID: 27067657. 3. Martin YC. The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413. Int J Med Chem. 2011;2011:424535. doi: 10.1155/2011/424535. Epub 2011 Mar 24. Review. PubMed PMID: 25954518; PubMed Central PMCID: PMC4412209. 4. Rasheed N, Ahmad A, Singh N, Singh P, Mishra V, Banu N, Lohani M, Sharma S, Palit G. Differential response of A 68930 and sulpiride in stress-induced gastric ulcers in rats. Eur J Pharmacol. 2010 Sep 15;643(1):121-8. doi: 10.1016/j.ejphar.2010.06.032. Epub 2010 Jun 28. PubMed PMID: 20599913.