| Description | A66 is a specific and effective p110α inhibitor(IC50=32 nM). |
| In vitro | 在雄性CD1小鼠体内,A66（10 mg/kg）在丙酮酸盐耐量测试中增加葡萄糖产生.在SK-OV-3肿瘤组织中,A66（100 mg / kg）能够降低Akt/PKB 和p70 S6激酶的磷酸化,抑制肿瘤细胞生长. |
| In vivo | 对于p110α的致癌形式,如p110αE545K（IC50=30 nM）和p110αH1047R（IC50=43 nM）,A66能够显著抑制其发挥作用。 |
| Target activity | p110α:32 nM |
| molecular weight | 393.53 |
| Molecular formula | C17H23N5O2S2 |
| CAS | 1166227-08-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 1 mg/mL (2.54 mM) DMSO: 60 mg/mL (152.47 mM), Sonication is recommended. |
| References | 1. Jamieson S, et al. Biochem J, 2011, 438(1), 53-62. 2. Sun M, et al. Proc Natl Acad Sci U S A, 2010, 107(35), 15547-15552. 3. Smith GC, et al. Biochem J, 2012, 442(1), 161-169. |