| Description | A-85380 is an agonist of nicotinic acetylcholine receptor. |
| Synonyms | A85380, A-85380 dihydrochloride, A 85380, A-85380 |
| molecular weight | 237.13 |
| Molecular formula | C9H14Cl2N2O |
| CAS | 174740-86-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lagarde J, Sarazin M, Chauviré V, Stankoff B, Kas A, Lacomblez L, Peyronneau MA, Bottlaender M. Cholinergic Changes in Aging and Alzheimer Disease: An [18F]-F-A-85380 Exploratory PET Study. Alzheimer Dis Assoc Disord. 2016 Sep 27. [Epub ahead of print] PubMed PMID: 27680780. 2. Le Foll B, Chefer SI, Kimes AS, Stein EA, Goldberg SR, Mukhin AG. Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates. Psychopharmacology (Berl). 2016 May;233(10):1829-35. doi: 10.1007/s00213-016-4250-9. PubMed PMID: 26911381; PubMed Central PMCID: PMC4846528. 3. Miyauchi M, Neugebauer NM, Oyamada Y, Meltzer HY. Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition. Behav Brain Res. 2016 Mar 15;301:204-12. doi: 10.1016/j.bbr.2015.10.044. PubMed PMID: 26519556. 4. Ogunjirin AE, Fortunak JM, Brown LL, Xiao Y, Dávila-García MI. Competition, Selectivity and Efficacy of Analogs of A-84543 for Nicotinic Acetylcholine Receptors with Repositioning of Pyridine Nitrogen. Neurochem Res. 2015 Oct;40(10):2131-42. doi: 10.1007/s11064-015-1705-z. PubMed PMID: 26508288; PubMed Central PMCID: PMC4741274. |