| Description | A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with no effect on drug-sensitive parent P388 cells. |
| Synonyms | A-30312, A30312 |
| molecular weight | 328.84 |
| Molecular formula | C19H21ClN2O |
| CAS | 144092-65-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kadam S, Maus M, Poddig J, Schmidt S, Rasmussen R, Novosad E, Plattner J, McAlpine J. Reversal of multidrug resistance by two novel indole derivatives. Cancer Res. 1992 Sep 1;52(17):4735-40. PubMed PMID: 1355008. |