| Description | A 1120 is a nonretinoid retinol-binding protein 4 (RBP4) antagonist (Ki: 8.3 nM), which disrupts the interaction between RBP4 and its binding partner transthyretin. |
| In vitro | A 1120在小鼠RBP4上的IC50值为66 nM，在人类RBP4上的IC50值为90 nM [1]。 |
| Target activity | RBP4:ki:8.3 nM |
| molecular weight | 392.37 |
| Molecular formula | C20H19F3N2O3 |
| CAS | 1152782-19-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 95 mg/mL (242.12 mM), Sonication is recommended. |
| References | 1. Motani A, et al. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem. 2009 Mar 20;284(12):7673-80. 2. Dobri N, et al. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):85-95. 3. Xue C, Tian Y, Zhang J, Zhao Y, Zhan J, Fang W, Zhang L. Efficacy of BIBF 1120or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo.Drug Des Devel Ther. 2016 Mar 15;10:1173-80 |