| Description | 8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure. |
| Synonyms | 8-iso Prostaglandin E2 |
| molecular weight | 352.47 |
| Molecular formula | C20H32O5 |
| CAS | 27415-25-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | PBS (pH 7.2): >5 mg/mL (from PGE2) DMSO: >100 mg/mL (from PGE2) Ethanol: >100 mg/mL (from PGE2) DMF: >100 mg/mL (from PGE2) |