| Description | 8-Deazafolic acid is a potent folate-dependent bacteria inhibitor, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469), and to have activity against lymphoid leukemia L1210 in mice. |
| Synonyms | NSC-173522, NSC173522, NSC 173522 |
| molecular weight | 440.41 |
| Molecular formula | C20H20N6O6 |
| CAS | 51989-25-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Temple C Jr, Kussner CL, Rose JD, Smithers DL, Bennett LL Jr, Montgomery JA. New synthesis of N-[4-[[(2-amino-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glut amic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives. J Med Chem. 1981 Oct;24(10):1254-8. PubMed PMID: 6948961. 2. Oatis JE Jr, Hynes JB. Sycnthesis of quinazoline analogues of folic acid modified at postion 10. J Med Chem. 1977 Nov;20(11):1393-6. PubMed PMID: 915899. 3. Hynes JB, Eason DE, Garrett CM, Colvin PL Jr. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogues of folic and isofolic acids. J Med Chem. 1977 Apr;20(4):588-91. PubMed PMID: 850245. 4. DeGraw JI, Kisliuk RL, Gaumont Y, Baugh CM. Antimicrobial activity of 8-deazafolic acid. J Med Chem. 1974 Apr;17(4):470-1. PubMed PMID: 4208536. |