| Description | 8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells. |
| In vitro | 8-azaadenosine (8-aza-AR) was a potent inhibitor of purine synthesis de novo, but 8-aza-HR, at concentrations much higher than the inhibitory concentration of 8-aza-AR, did not inhibit this process.?In H. Ep. 2 cells, 8-aza-HR blocked the conversion of orotic acid to uridine nucleotides and caused an accumulation of orotidine.?This inhibition of pyrimidine biosynthesis apparently does not contribute significantly to the cytotoxicity of 8-aza-HR because uridine provided no degree of reversal of its inhibition of the growth of cell cultures. |
| molecular weight | 268.23 |
| Molecular formula | C9H12N6O4 |
| CAS | 10299-44-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 250 mg/mL (932.04 mM), Sonication is recommended. |
| References | 1. Bennett L L , Allan P W . Metabolism and Metabolic Effects of 8-Azainosine and 8-Azaadenosine[J]. Cancer Research, 1976, 36(11 Pt 1):3917. |