| Description | 740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K. |
| In vitro | 740 Y-P是一种合成的生物素化肽。在最低浓度(1 mg/mL)下，740 Y-P便能刺激细胞增生。无论是否存在血清(0.5%)，该肽均能促进细胞增生，在有血清的情况下，观察到最大反应浓度为50 mg/mL。740Y-P肽刺激细胞增生的能力高度特异，这并非细胞膜渗透性SH2结合域肽的一般特性[1]。740Y-P在通过已建立的PI 3激酶-Akt生存级联路径促进神经细胞存活方面，与生长因子(FGF2)效果相当。PDGFR740Y-P肽刺激神经细胞存活的效果是剂量依赖性的，并且不需要胰岛素[2]。 |
| Synonyms | PDGFR 740Y-P(TFA), 740 Y-P(TFA), 740YPDGFR(TFA) |
| molecular weight | 3384.73 |
| Molecular formula | C143H223F3N43O41PS3 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52. 2. Williams EJ, Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol Cell Neurosci. 1999 Apr;13(4):272-80. |
| Citations | 1. Zhang, Chaochao, et al. Mechanisms Involved in the Anti-Tumor Effects of Toosendanin in Glioma Cells. Cancer Cell International. 2021, 21(1): 1-13. 2. Zhang C, Gao H, Liu Z, et al. Mechanisms involved in the anti-tumor efects of Toosendanin in glioma cells. Cancer Cell International. 2021, 21(1): 1-13 |