| Description | 7-Hydroxyisoflavone against Enterovirus 71 in vitro. |
| In vitro | 7-hydroxyisoflavone 对EV71具有活性。7-hydroxyisoflavone 对三种不同的EV71毒株展示了强大的抗病毒活性。其50%抑制浓度范围通过细胞病变效应测定法确定为3.25至4.92 μM。7-hydroxyisoflavone 能够以剂量依赖的方式减少EV71病毒RNA和蛋白质的合成。时间进程研究表明，在EV71接种后的指定时间（0-6小时）处理Vero细胞，7-hydroxyisoflavone 显示出显著的抗病毒活性[1]。 |
| molecular weight | 238.24 |
| Molecular formula | C15H10O3 |
| CAS | 13057-72-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 25 mg/mL (104.94 mM) |
| References | 1. Wang H Q , Meng S , Li Z R , et al. The antiviral effect of 7-hydroxyisoflavone against Enterovirus 71\r, in vitro[J]. Journal of Asian Natural Products Research, 2013, 15(4):382-389. 2. Miao J , Cui H , Jin J , et al. Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging[J]. Chem Commun, 2015, 51(5):881-884. |