| Description | 7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with anti-addictive properties and can be used in the study of neuropathic pain. |
| In vitro | 7-BIA 抑制重组人类 PTPRD 和重组人类 PTPRS ，其半抑制浓度(IC50)值分别约为1-3 μM 和 40 μM[1]。 |
| In vivo | 通过剂量为10-20 mg/kg的腹腔注射，7-BIA能够减少有经验的野生型小鼠对可卡因的自我给药行为[1]。 |
| Animal experiments | Animal Model: WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions). Dosage: 10 mg/kg, 20 mg/kg. Administration: Given i.p.; only once |
| Target activity | PTPRD:1-3 μM (Human), PTPRS:40 μM (Human) |
| molecular weight | 294.3 |
| Molecular formula | C15H18O6 |
| CAS | 1313403-49-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (271.83 mM), Sonication is recommended. Ethanol: 30 mg/mL (101.94 mM) |
| References | 1. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosinephosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11597-11602. |