| Description | 6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2. |
| Synonyms | 6β-Prostaglandin I1 |
| molecular weight | 354.487 |
| Molecular formula | C20H34O5 |
| CAS | 62770-50-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: >10 (from 6b-PGI1) DMSO: >5 (from 6b-PGI1) PBS (pH 7.2): >80 μg (from 6b-PGI1) Ethanol: >20 mg/mL (from 6b-PGI1) |