| Description | 6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside, a metabolite of Azathioprine, and a low molecular weight gel.6-Thioguanosine is immunosuppressive and has been used to study the formation of the RNA double helix. |
| Synonyms | 6-Mercaptoguanosine, NSC29422, NSC 29422, NSC-29422 |
| molecular weight | 299.31 |
| Molecular formula | C10H13N5O4S |
| CAS | 85-31-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 6.88 mg/mL (22.97 mM), Sonication is recommended. |
| References | 1. Amedeo De Nicolò, et al. UPLC-MS/MS method for quantification of the azathioprine metabolites 6-mercaptoguanosine and 6-methylmercaptopurine riboside in peripheral blood mononuclear cells. J Pharm Biomed Anal. 2014 Sep;98:271-8. 2. Supandi S, Harahap Y, Harmita H, Andalusia R. Quantification of 6-Mercaptopurine and Its Metabolites in Patients with Acute Lympoblastic Leukemia Using Dried Blood Spots and UPLC-MS/MS. Sci Pharm. 2018 Apr 25;86(2). pii: E18. doi: 10.3390/scipharm86020018. PubMed PMID: 29693618; PubMed Central PMCID: PMC6027686. 3. Miyata S, Yamada T, Isozaki T, Sugimura H, Xu YZ, Suzuki T. Absorption Characteristics and Quantum Yields of Singlet Oxygen Generation of Thioguanosine Derivatives. Photochem Photobiol. 2018 Jul;94(4):677-684. doi: 10.1111/php.12900. Epub 2018 Mar 31. PubMed PMID: 29420844. 4. Ashwood B, Ortiz-Rodríguez LA, Crespo-Hernández CE. Photochemical relaxation pathways of S(6)-methylthioinosine and O(6)-methylguanosine in solution. Faraday Discuss. 2018 Apr 17;207(0):351-374. doi: 10.1039/c7fd00193b. PubMed PMID: 29372193. |