| Description | 6-Methoxydihydrosanguinarine is a natural product. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml |
| In vivo | 6-Methoxydihydrosanguinarine(6ME)，一种从Hylomecon种提取的苯并菲安德林类生物碱，可能具有作为化疗化合物的潜力。6ME以浓度和时间依赖的方式抑制HepG2细胞的生长（IC50=3.8±0.2μM，在6小时孵育后）。用6ME处理HepG2细胞会导致线粒体细胞色素c的释放，随后激活caspase蛋白酶，并进一步促使poly(ADP-ribose)聚合酶的蛋白水解切割。6ME提高了p53和bax的表达，降低了bcl-2的表达。6ME的细胞毒作用是由时间依赖的活性氧种的产生介导的。HepG2细胞与维生素C预孵育可以减少p53和bax的表达，并抑制细胞色素c的释放、caspase的下游激活和poly(ADP-ribose)聚合酶的切割，从而抑制了6ME诱导的凋亡效应。 |
| Target activity | SF-268 cells:0.54 μM (IC50), MCF-7 cells:0.61 μM (IC50) |
| molecular weight | 363.36 |
| Molecular formula | C21H17NO5 |
| CAS | 72401-54-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (137.6 mM) |
| References | 1. Yin H Q , Kim Y H , Moon C K , et al. Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells[J]. Biochemical Pharmacology, 2005, 70(2):242-248. 2. Zou HL, et al. Alkaloids from Macleaya cordata and their cytotoxicity assay. Zhongguo Zhong Yao Za Zhi. 2015 Feb;40(3):458-62. |