| Description | 6-(γ,γ-Dimethylallylamino)purine (Triacanthine), which is a plant growth substance, shows hypertensive and antitumor activity, also cardiotonic, antispasmodic and a respiratory analeptic. |
| In vitro | 6-(γ,γ-Dimethylallylamino)purinee显著抑制了EJ细胞的增殖（IC50为600μM）。流式细胞术分析揭示，细胞在G1期被阻滞，而凋亡细胞则以剂量依赖的方式在sub-G1期积累。6-(γ,γ-Dimethylallylamino)purinee通过阻碍周期蛋白依赖性激酶与cyclins之间的复合体形成，从而上调细胞周期抑制因子p21WAF1和p27KIP1，抑制了G1-S过渡。 |
| In vivo | 在一项体内研究中，6-(γ,γ-Dimethylallylamino)purinee显著限制了异种移植瘤的生长。有趣的是，尽管cisplatin在5-mg/kg剂量后导致了明显的体重下降，6-(γ,γ-Dimethylallylamino)purinee却未引起体重减轻、行为异常、生化参数改变或组织染色。单剂口服急性毒性测试(6-(γ,γ-Dimethylallylamino)purinee 2,000mg/kg)未通过血液生化测试和组织器官染色产生不良的细胞毒性效应。 |
| Synonyms | N6-(2-lsopentenyl)adenine, 三刺皂荚碱, Triacanthine |
| molecular weight | 203.24 |
| Molecular formula | C10H13N5 |
| CAS | 2365-40-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 2.03 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Shin SS, et al. Triacanthine exerts antitumor effects on bladder cancer in vitro and in vivo. Phytomedicine. 2019 Aug 9;64:153069. |