| Description | 5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, capable of being synthesized by androgen-responsive prostate cancer cells under conditions of starvation. |
| In vitro | 在人类成纤维细胞中，黄体酮被转化为 5α-Pregnane-3β,6α-diol-20-one [1]。孕烯醇酮和黄体酮在C4.2细胞系中被积极地代谢为5α-Pregnane-3β,6α-diol-20-one，转化率在24小时和18小时分别接近完全。对于早期类固醇前体而言，5α-Pregnane-3β,6α-diol-20-one 的优先形成不依赖于CYP17A1，而是依赖于3β-HSD活性[2]。 |
| molecular weight | 334.49 |
| Molecular formula | C21H34O3 |
| CAS | 21853-11-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (298.96 mM), Sonication is recommended. |
| References | 1. Zhang J, et al. Progesterone metabolism in human fibroblasts is independent of P-glycoprotein levels and Niemann-Pick type C disease. J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):123-31. 2. de Mello Martins AGG, et al. CYP17A1-independent production of the neurosteroid-derived 5α-pregnan-3β,6α-diol-20-one in androgen-responsive prostate cancer cell lines under serum starvation and inhibition by Abiraterone. J Steroid Biochem Mol Biol. 2017 Nov;174:183-191. |