| Description | 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound which is a 5-HT 3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT 3 agonist and 2-methyl-5-HT, and exhibits anti-depressant effect in mice [1]. |
| In vitro | 5-HT3 antagonist 5 (compound 4c) shows 5-HT 3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT 3 agonist, 2-methyl-5-HT, with pA 2 value of 5 [1]. |
| In vivo | 5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) reduces the duration of immobility and shows anti-depressant effect in FST mice [1]. Animal Model: Swiss albino mice (23 ± 2 g) [1] Dosage: 1 mg/kg Administration: Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration Result: Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity. |
| molecular weight | 279.29 |
| Molecular formula | C16H13N3O2 |
| CAS | 901599-43-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |