| Description | 5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adenosyl)-L-methionine can be converted to 5'-chloro-5'-deoxyadenosine in a reaction catalyzed by a SAM-dependent chlorinase. Through a 7-step route, 5'-chloro-5'-deoxyadenosine can be converted to chloroethylmalonyl-CoA, which has been shown to be involved in the biosynthesis of the anticancer agent salinosporamide A in the marine bacterium S. tropica. |
| molecular weight | 303.7 |
| Molecular formula | C10H14ClN5O4 |
| CAS | 698999-09-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL Ethanol: 0.5 mg/mL DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL DMF: 30 mg/mL |
| References | 1. Eustáquio, A.S., McGlinchey, R.P., Liu, Y., et al. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine Proc. Natl. Acad. Sci. USA 106(30), 12295-12300 (2009). |
5'-chloro-5'-Deoxyadenosine (hydrate)
CAS No.: 698999-09-6
5'-chloro-5'-Deoxyadenosine (hydrate) is a nucleoside analog used as a substrate in polyketide biosynthesis. S-(5'-adeno
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