| Description | 5-A-RU-PABC-Val-Cit-Fmoc is one of the precursors of 5-A-RU, a small molecule mucosal-associated MAIT activator that is a precursor for bacterial synthesis of riboflavin. |
| In vitro | 体外和体内前药的分析显示，与 5-A-RU 相比，5-A-RU-PABC-Val-Cit-Fmoc 能诱导更高水平的粘膜相关不变 T (MAIT) 细胞活化[1]。 |
| molecular weight | 903.93 |
| Molecular formula | C43H53N9O13 |
| CAS | 2677841-58-4 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (132.75 mM), Sonication is recommended. |
| References | 1. Joshua Lange, et al. The Chemical Synthesis, Stability, and Activity of MAIT Cell Prodrug Agonists That Access MR1 in Recycling Endosomes. ACS Chem Biol. 2020 Feb 21;15(2):437-445. 2. Corbett AJ, et al. T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature. 2014 May 15;509(7500):361-5. 3. Eckle SB, et al. Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells. J Biol Chem. 2015 Dec 18;290(51):30204-11. 4. Soudais C, et al. In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin PrecursorDerivatives Activating Mouse MAIT Cells. J Immunol. 2015 May 15;194(10):4641-9. |