| Description | 4-PPBP maleate is a potent σ1 receptor (ligand) agonist. 4-PPBP maleate can be considered a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression. 4-PPBP maleate has neuroprotective properties. |
| In vitro | 在原始神经元中，4-PPBP maleate 诱导 ERK1/2 磷酸化。[3] |
| In vivo | 在大鼠中，通过静脉（i.v.）注射4-PPBP maleate（1 μmol/kg）后，可在短暂局部缺血后减少脑损伤。[2] |
| molecular weight | 409.52 |
| Molecular formula | C25H31NO4 |
| CAS | 201216-39-9 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: < 10.24 mg/mL DMSO: 225.0 mg/mL (549.4 mM), Sonication is recommended. |
| References | 1. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338. 2. Takahashi H, et al. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27(11):2120-2123. 3. Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59(6):416-424. |